Biobehavioral Mechanisms of Topiramate and Drinking
This project is the latest study in a program of research characterizing the mechanisms of action underlying contemporary medications for treating alcoholism. Topiramate is a widely used anticonvulsant medication that has diverse neuropharmacological effects on the GABA and glutamate neurotransmitter systems and has recently been demonstrated to be efficacious in the treatment of alcoholism. We are conducting a study examining the effects of topiramate on drinking and an array of other variables reflecting potential mechanisms of the medication’s effects using ecological momentary assessment and multiple human laboratory paradigms. This research is funded by the National Institute on Alcohol Abuse and Alcoholism.